Potassium trifluoroacetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 26 nov 1998 to 03 nov 2000

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study not GLP, but following the OECD guideline.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2000

Report date:

2000

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Deviations:

not specified

GLP compliance:

no

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Potassium trifluoroacetate

EC Number:

220-877-5

EC Name:

Potassium trifluoroacetate

Cas Number:

2923-16-2

Molecular formula:

C2HF3O2.K

IUPAC Name:

potassium trifluoroacetate

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Harlan Nossan S.r.l, Italy
- Age at study initiation:
- Weight at study initiation: males: between 244 and 245 g; females: between 154 and 163 g
- Fasting period before study: an overnight
- Diet (e.g. ad libitum): available 4 hours after dosing
- Water (e.g. ad libitum):

IN-LIFE DATES: From 07 march 2000 to 28 march 2000

No more data available

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Remarks:

0.5%

Doses:

500 and 2000 mg/k bw

No. of animals per sex per dose:

3 females at 500 mg/kg
3 males at 2000 mg/kg

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed for clinical signs immediately upon dosing, approximately 1, 2, 4 hours after dosing and daily thereafter for a total of 14 days.
Animals were weighted on allocation to the study, prior to dosing (day 1) and on days 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality occured during the study

Clinical signs:

other: 500 mg/kg: piloerection observed following dosing. Recovery within 2 days. 2000 mg/kg: piloerection an hunched posture observed following dosing. Recovery within 6 days.

Gross pathology:

No abnormalities observed.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Potassium trifluoroacetate is not classified according to the CLP 1272/2008

Executive summary:

In a study (RTC, 2000), Sprague-Dawley rats received Potassium trifluoroacetate at doses of 500 and 2000 mg/kg in vehicle carboxymethylcellulose (CMC). The animals were observed for 14 days. No mortality was observed. Clinical signs: piloerection at 500 mg.kg (recovery within 2 days); piloerection and hunched posture at 2000 mg/kg with recovery within 6 days. The LD50 was higher than 2000 mg/kg.

In these conditions, Potassium trifluoroacetate is not harmful by ingestion, according to CLP 1272/2008/EC criteria.