Registration Dossier
Registration Dossier
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EC number: 220-877-5 | CAS number: 2923-16-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
By analogy with TFANa, TFAK is considered as having no inhibiting effect on activated sludge at 1000 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
No data on potassium trifluoroacetate is available for this endpoint. However, a reliable key study is available for sodium trifluoroacetate which is used in a read-across approach. The results expressed in TFANa is directly applied to TFAK in a worst case approach (i.e. the molecular weight of Na is lower than the molecular weight of K).
The influence of the test item Sodium trifluoroacetate on the activated sludge was evaluated by measuring the respiration rate under defined conditions, according to EU Method C.11 and OECD 209 Guidelines. The respiration rate (oxygen consumption) of an aerobic activated sludge fed with a standard amount of synthetic sewage was measured in the presence of various concentrations of the test item (10, 32, 100, 320 and 1000 mg/L) after an incubation period of 3 hours.
The inhibition of the bacterial respiration activity was in the range of 3.2 to 9.7% for the test concentrations of 10 to 1000 mg/L. The maximum inhibition was 9.7% at a test concentration of 100 mg/L.
Based on measured inhibition rates, the 3 -hour EC10, EC20 and EC50 could not be quantified because up to the highest nominal test concentration of 1000 mg/L less than 10% inhibition was noted after three hours incubation. A dose response at both test concentrations could not be observed. The maximum deviation in respiration rates was 9.7% at a Sodium trifluoroacetate concentration of 1000 mg/L. Nevertheless, the 3 -hour EC20 and EC50 are clearly higher than 1000 mg NaTFA/L (832 mg TFA/L) under the present test conditions. Even the test was not designed for a NOEC determination, the NOEC of Sodium trifluoroacetate may be established above 1000 mg/L (832 mg TFA/L).
The positive control 3,5 -Dichlorophenol was tested in the same way as the test item with nominal concentrations of 3.2, 10 and 32 mg/L. The 3 -hour EC50 was found to be 12.0 mg/L thus laying in the range of 5 -30 mg/L recommended by the test guidelines. The result confirms the suitability of the activated sludge used.
By analogy, potassium trifluoroacetate is considered as having no inhibiting effect on activated sludge at 1000 mg/L.
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