Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-877-5 | CAS number: 2923-16-2
Endpoint summary
Administrative data
Description of key information
Additional information
READ-ACROSS JUSTIFICATION
When environmental data required by REACH regulation are missing for TFAK, a read-across approach with Sodium trifluoroacetate (TFANa, CAS RN: 2923-18-4) is performed. This approach is justified by the information below:
1) Structural similarity
Both substances are trifluoroacetate salts and therefore have similar chemical structure. The only difference between two substances is the cation which is potassium for TFAK and Sodium for TFANa. As potassium and sodium are not toxic to the aquatic organisms, the toxicity effect of TFAK and TFANa should be the activity of the trifluoroacetate moiety. This supports the fact that they should show similar effect on organisms.
2) Similar bioavailability
Both substances are solid very soluble in water (water solubility at 25°C of 625 g/L for TFANa and 697 g/L for TFAK). They have a low volatility (Vapour pressure at 25°C of 10E-5 Pa for TFANa (QSAR) and < 10E-4 Pa for TFAK) and a low potential of bioaccumulation (LogKow values of -3.31 for TFANa (QSAR) and -3.12 for TFAK).
In the aquatic environment, both substances ionized into the trifluoroacetate anion and the K and Na cations. Therefore, the bioavailability of the trifluoroacetate moiety should be the same for both substances. Additionally, as the degradability of the cations K and Na is not applicable, the degradability of the trifluoroacetate moiety should be take into account to assess the degradability of TFAK and TFANa.
Based on the above information, both substances should show similar bioavailability to organisms in the environment, and similar fate and behaviour in and between the environmental compartments.
3) Similar ecotoxicity potential
Data on aquatic toxicity of TFAK is only available for Daphnids. The 48-hour EC50 for Daphnia magna is >100 mg/L (Study performed in 2000) and no immobility has been observed in this study. Acute toxicity data on the same species,Daphnia magna, is available for TFANa, and the 48-hour EC50 was higher than 1200 mg/L and no immobility has been observed in this study. This suggests that both substances should have similar toxicity to the aquatic organisms.
To conclude, based on the similar chemical structure, bioavailability and ecotoxicity potential, the ecotoxicity data and degradation information obtained on TFANa can be used to assess the environmental profile of TFAK. Data on TFANa are reported in the REACH registration dossier of trifluoroacetic acid (CAS RN: 76-05-1), submitted by the same registrant as the present dossier. In order to avoid repeating all data and information on TFANa, which can make the read-across approach difficult to understand, only key studies obtained on TFANa are reported in the read-across approach in the present dossier for TFAK.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
