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EC number: 422-600-5
CAS number: 73936-91-1
The oral repeated dose toxicity of the test
substance has been determined in a subchronic GLP study with rats (males
and females) according to OECD Guideline 408 (90-days, 7 days a week, of
oral exposure (gavage) at doses of 0, 2, 10, 100 and 1000 mg/kg bw/day).
The test substance was on the whole well tolerated up to and including
the highest dosage administered because no signs of toxicity were
observed. One animal, which was found dead during the study, was
subjected to a gross postmortem examination and all protocol-specified
tissues were examined microscopically, no treatment related effects were
observed. Oral gavage administarion of the test material, for at least
90 days to rats at the highest dose level of 1000 mg/kg/day did not
cause histomorphologic lesions in any of the representative sections of
tissues. Accordingly, a NOEL and NOAEL of > 1000 mg/kg bw/day have been
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