Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.

Data source

Reference
Reference Type:
other: SNIF
Title:
Unnamed
Year:
1997

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
not specified
GLP compliance:
yes
Type of method:
other: The log Pow was calculated by MedChem CLOGP 2.12
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
10.605
Temp.:
20 °C
Remarks on result:
other: The pH value at which the partition coefficient (at 20 °C) was determined cannot be provided because the SNIF file (provided by ECHA) doesn't contain this information.

Applicant's summary and conclusion

Conclusions:
logPow = 10.605 (at 20°C)
Executive summary:

The partition coefficient (n-octanol/water) of the test substance was determined to be 10.605 at 20 °C by estimation in a GLP study according to EU Method A.8 (as logPow of the substance is outside the range for reliable experimental determination of Log Pow by either the Shake Flask or HPLC method).