Registration Dossier
Registration Dossier
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EC number: 203-354-6 | CAS number: 106-02-5
Endpoint summary
Administrative data
Description of key information
Additional information
Three key studies are available to assess the terrestrial toxicity of the substance. These studies were performed on a read-across substance (EC Number: 422-320-3). This supporting substance is considered adequate for read-across purposes (see Iuclid section 13 for justification).
The first study (Shacklady, 2001) is an acute study, performed according to the OECD Guideline 207 with GLP statement, on the earthworm Eisenia foetida in an artificial soil. No acute effects were observed, therefore, the 14-d LC50 for the test substance to earthworms based on nominal test concentrations was greater than 1000 mg/kg dw, the maximum concentration tested.
The second study (Winkelmann, 2013) is a chronic study, performed according to the OECD Guideline 222 with GLP standards, on the earthworm Eisenia foetida, in an artificial soil. No chronic effect were observed, therefore, the 56d-NOEC based on mortality, growth and earthworm reproduction based on initial measured test concentrations was >= 544 mg/kg soil dry weight, the maximum concentration tested.
The third study (Teixeira, 2002) is an acute study, performed according to the OECD Guideline 208 with GLP standards, on seedling emergence and dry shoot weight of three plant species: oat (Avena sativa), soybean (Glycine max) and tomato (Lycopersicon esculentum). No toxicity was observed for all species during this period, therefore, the 26d- EC50 were greater than 1000 mg/Kg, the maximum concentration tested.
In conclusion, the acute EC50/LC50 values were greater than 1000 mg/Kg dw and the chronic NOEC value was >= 544 mg/Kg dw.
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