Registration Dossier
Registration Dossier
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EC number: 203-354-6 | CAS number: 106-02-5
Endpoint summary
Administrative data
Description of key information
Additional information
No information about the abiotic degradation of the substance is available. But as the substance is readily biodegradable (two reliable screening studies fulfilling the 10-day window), the substance is considered rapidly degradable in the environment. Therefore, no environmental persistence of the substance is anticipated and no further tests on degradation in the environment are necessary.
The adsorption potential of the substance was evaluated in a GLP OECD 121 study on a read-across substance (EC number: 422-320-3) in which a Koc of 44500 was determined. The substance can be considered as strongly binding to soil and sediment and therefore immobile in soil and sediments based on the system proposed by McCall et al. (1980). This supporting substance is considered adequate for read-across purposes (see Iuclid section 13 for justification).
Furthermore, it is assumed that the substance evaporates from water surfaces under environmental conditions due to its high Henry’s Law constant (68.1 Pa.m3/mol at 25°C).
The BCF of the substance was calculated using the BCF/BAF method of Arnot-Gobas including biotransformation rate, resulting in a BCF value between 500 and 1000 regardless of the trophic level. The B criterion is not fulfilled for the substance and thus, the substance is considered to be not bioaccumulative. It would be technically challenging to perform a BCF study on fish at concentrations below the NOEC (of 0.027 mg/L) as apart from the low water solubility, the substance also has a high adsorption coefficient and readily biodegrades. Furthermore the ready degradation implies rapid metabolism so significant bioaccumulation is not expected and an experimental BCF study would not be expected to add significantly to the knowledge already gained for bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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