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Toxicity to microorganisms

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Description of key information

EC50 (3 h): > 1000 mg/L (nominal, OECD 209) based on read across from CAS 23432-65-7

Key value for chemical safety assessment

Additional information

Experimental data on the toxicity of methyl-N-[3-(trimethoxysilyl)propyl]carbamate (CAS 23432-62-4) on the respiration of microorganisms are not available. Therefore, in accordance with the Regulation (EC) No. 1907/2006 Annex XI, 1.5 “Grouping of substances and read across” and the read across assessment framework (RAAF, ECHA 2017) a read across from the analogue substance methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432-65-7) has been performed. Details on the read-across justification can be found in the analogue justification attached in IUCLID Section 13.

 

One experimental study is available investigating the toxicity of methyl-N-{[dimethoxy(methyl)silyl]methyl}carbamate (CAS 23432-65-7) to activated sludge microorganisms (2003). This study was performed according to the OECD guideline 209 and GLP. Activated sludge from a domestic sewage treatment plant was exposed to nominal concentrations of 10, 32, 100, 320 and 1000 mg/L. Since the substance is expected to hydrolyse rapidly in contact with water (DT50: 1.9 h at 20 - 25 °C, pH 7), the result from this study mainly investigated the possible effects of the hydrolysis products (Methyl-N-{[dihydroxy(methyl)silyl]methyl}carbamate und methanol). During stock solution preparation it was ensured by intensive stirring that the parent substance hydrolyses and mainly the hydrolysis products are tested. After an exposure of 3 h an inhibition of respiration of 10.8% was recorded in the highest concentration tested, resulting into an EC50 (3 h) > 1000 mg/L.

Based on the results of the analogues substance and the attached read across justification, similar effects are expected by the target substance methyl-N-[3-(trimethoxysilyl)propyl]carbamate (CAS 23432-62-4).