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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1974
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
Substance weight increase instead of decrease during IRT, probably due to hygroscopic properties of test substance. Therefore one can not be sure whether the animals were exposed to any test substance at all.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report Date:
1974

Materials and methods

GLP compliance:
no
Test type:
other: Inhalation Risk Test (IRT)
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
- Substance type: Borated Glycol Ether
- Physical state: Clear colourless liquid
- Lot/batch No.: 4200 (SNC Sample No.); Indent 9450/9486
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: Not provided

Test animals

Species:
rat
Strain:
Sprague-Dawley
Remarks:
Gassner-Ratten (Gassner-rat)
Sex:
male/female
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Rate of air: 200 liter air/hour

"Inhalation einer mit Dampf bei C gesättigten Atmosphäre: 20 °C. Zur Sättigung wurde durch eine ca. 5 cm hohe Schicht des Produktes Luft geleitet"
(Inhalation of a vapour saturated atmosphere at 20 °C. In order to obtain saturation of the atmosphere, air was passed through a 5 cm column of the product.)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
No. of animals per sex per dose:
3
Control animals:
yes
Remarks:
Exposure to pure air.
Details on study design:
- Exposure time: 8 h
- Duration of observation period following administration: 7 days
Further details were not provided.

Results and discussion

Mortality:
No mortalities within 8 h exposure period and 7 day observation period.
Clinical signs:
No effects on clinical signs.
Body weight:
No effects on body weight.
Gross pathology:
No effects on gross pathology.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
Migrated information
Conclusions:
No mortalities within 8 h exposure period.
Executive summary:

A nominal concentration could not be calculated because the substance gained weight instead of lost weight during the test.