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EC number: 268-074-9
CAS number: 68002-61-9
study was conducted to determine the acute oral toxicity potential of
the test substance C16-18 and C18-unsatd. TMAC (50% active in
isopropanol and water) in Sprague-Dawley rats, according to OECD
Guideline 401, in compliance with GLP. Four groups of 10 fasted animals
(five males and five females) were administered an oral gavage dose of
the test substance (i.e., 50% active ingredient) at doses of 1,000,
1,260, 1,587 and 2,000 mg/kg bw. The animals were observed for 14 days
and were then sacrificed and subjected to gross pathological
examination. Mortality was observed at all doses (females: 2/5, 4/5,
2/5, 4/5; males: 0/5, 2/5, 5/5, 5/5, at each respective dose) with
percentages ranging from 60-90 at ≥1,260 mg/kg bw. Major signs of
toxicity noted in decedent and surviving animals were hunched posture,
lethargy, pilo-erection, decreased respiratory rate and diarrhoea. All
animals showed expected body weight gain during the second week of the
study. Necropsy of decedents revealed abnormally red lungs, dark livers,
haemorrhage and ulceration of the gastric mucosa and congestion of the
small intestines. Surviving animals necropsied at termination showed
white raised areas on the non-glandular region of the stomach or general
white thickening of this region. Under the test conditions, the LD50 was
determined to be 1,260 mg/kg bw for males/females (i.e., equivalent to
630 mg a.i./kg bw) (Jones, 1987).
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