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EC number: 268-074-9
CAS number: 68002-61-9
This substance is identified by SDA Substance Name: C16-C18 and C18 unsaturated alkyl trimethyl ammonium chloride and SDA Reporting Number: 11-045-00.
For result tables, kindly refer to the
attached background material section of the IUCLID.
study was conducted to determine the skin irritation potential of the
test substance, C16 -18 and C18 -unsatd. TMAC (50% active) in rabbits,
according to a method similar to OECD Guideline 204. Six rabbits (both
sexes) were treated with 0.5 mL of undiluted test substance (50% active
ingredient) in an occlusive patch fixed with adhesive tape and wrapped
with an impervious material, for 4 h. Observations were made at 4 h, 48
h and 10 days post-exposure. If the test substance appeared to be
corrosive after 4 h, another study was conducted with a 1 h exposure
period under similar test conditions. The Draize scoring criteria was
used for evaluating the corrosion potential. At 4 h, very slight to
well-defined erythema, very slight ischemia and very slight oedema were
observed, with an average irritation score of 4/8. At 48 h, there was
well-defined to moderate erythema, very slight to slight ischemia and
very slight or slight oedema and the average irritation score was 5.4/8.
After 10 days, slight to distinct incrustation and decreased hair growth
was observed. After an exposure period of 1 h, very slight erythema was
observed with an average irritation score of 0.85/8. After 48 h, there
was very slight to moderate erythema and very slight or slight oedema
and the average irritation score was 1.25/8. No skin effects were
observed after 10 days. Under the study conditions, the undiluted test
substance (50% active ingredient) was corrosive after 4 h of occlusive
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