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EC number: 292-429-7
CAS number: 90622-29-0
CAL 145 comprises alkenes C13-14 hydroformylation products with
read-across from the chemically-similar Alchisor CAL 123 as defined in
the `Read-Across Justification Document'. Where
toxicological data exist for Alchisor CAL 123, these are representative
of the Alchisor CAL 145 substance.
reliable (Klimsich 1; Klimisch 2 when used for read-across) GLP
compliant study conducted according to both OECD 406 and EPA OPPTS
870.2600 guidelines Alchisor CAL 123 was topically applied to 30
short-haired male and female albino guinea pigs.
group animals (10/sex) received three pairs of intradermal injections
(adjuvant, a solution of test substance in corn oil, and a 50:50 mixture
of adjuvant and the test substance solution) followed one week later by
a single topical application of the undiluted test substance. Ten
additional animals (5/sex) served as a control group. Control animals
were treated at the same time periods and locations but with the vehicle
used in place of the test substance solution. Two weeks after the
topical application, the test animals were challenged with a second
topical application of the undiluted test substance at a virgin test
site. Control animals were also given a topical application of undiluted
test substance. The percentage of animals exhibiting erythema with or
without edema after the challenge treatment was used to assign the test
substance a sensitization potency rating. Since none of the test animals
exhibited scores greater than 0, the test substance Alkenes, C11 -12,
hydroformylation products, distn. residues was given a sensitization
potency rating of non-sensitizer (Grade 0).
should be noted that during the study, two test animals and one control
animal died; deaths were not considered related to substance
findings do not warrant the classification of alkenes, C11 -12,
hydroformylation products, distillation residues (CAS No: 90622 -27 -8)
as a sensitiser under the new Regulation (EC) 1272/2008 on
classification, labeling and packaging of substances and mixtures (CLP)
or under the Directive 67/518/EEC for dangerous substances and Directive
1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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