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EC number: 292-429-7
CAS number: 90622-29-0
Waiver. This information will be submitted based on ECHA communication/decision number CCH-D-2114584879 -21 -01/F.
CAL 145 comprises alkenes C13-14 hydroformylation products and
read-across from the chemically-similar Alchisor CAL 123 has been used
in this hazard assessment as defined in the `Read-Across Justification
accordance with Column 2 of REACH Annex IX, the long-term aquatic
toxicity to invertebrates study (required in Section 9.1.6) does not
need to be conducted for Alchisor CAL 145 as
the chemical safety assessment according to Annex I indicates that this
is not necessary. Adequate evidence exists for a waiver. It can be
concluded in read-across from the chemically-similar Alchisor CAL 123,
that it is unlikely that chronic toxicity to invertebrates will be
exhibited in the environment following exposure to Alchisor CAL 145 as
the substance is readily biodegradable and low toxicity to aquatic life. Therefore,
the data requirement for long-term toxicity to invertebrates is waived.
Below is a summary of the supporting evidence that Alchisor CAL 145
would be unlikely to cause long-term toxicity to invertebrates based on
rapid biodegradation and low acute toxicity. There are no reliable
measured or predicted data for chronic invertebrate studies relating to
Alchisor CAL 145 (or Alchisor CAL 123).
chemically-similar Alchisor CAL 123 has been shown in the reliable
(Klimisch 1; Klimisch 2 when used for read-across) study by Schaefer and
Matthews (2010) to be readily biodegradable in water. The test substance
biodegraded to an extent of 87.7% after 28 days and although the
biodegradation rate just missed the 10-day window threshold, this aspect
of the test is not applicable to mixtures where different components of
the mixture can biodegrade preferentially (reference TG 103C). It
is assumed that Alchisor CAL 145 will readily biodegrade in water and be
unavailable for long-term uptake by fish.
to Aquatic Organisms
toxicity of the chemically-similar Alchisor CAL 123 to aquatic organisms
is very low based on the evidence presented in this dossier. The
lowest measured toxicity was based on an algal test where the NOEL based
on algal growth was 25 mg/L. Acute toxicity to invertebrates and fish
was >100 mg/L based on 50% mortality. In
addition, because the substance has been deemed readily biodegradable,
it is unlikely that invertebrates would encounter long-term exposure to
the substance. Using
this evidence it is assumed that Alchisor CAL 145 represents a low
hazard and is not considered to be toxic (in PBT terms) to aquatic life.
summary, the data requirement for long-term toxicity to invertebrates is
being waived based on the evidence that the substance is readily
biodegradable and has low toxicity to aquatic life.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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