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EC number: 292-429-7
CAS number: 90622-29-0
Skin irritation: A reliable (Klimisch 1; Klimisch 2 when used for read-across) GLP compliant study with alkenes, C11-12, hydroformylation products, distillation residues in NZW rabbits was conducted according to EPA OPPTS 870.2500 (Acute Dermal Irritation). Following a 4 hour semi-occlusive exposure the test item was found to be not-irritating to skin (according to EU criteria).Eye Irritation: A reliable (Klimisch 1; Klimisch 2 when used for read-across) GLP compliant eye irritation study was conducted with alkenes, C11-12, hydroformylation products, distillation residues. The study was conducted in NZW rabbits according to EPA OPPTS 870.2400 (Acute Eye Irritation). The test item in this instance was reported to be not-irritating to eyes (according to EU criteria).
CAL 145 comprises alkenes C13-14 hydroformylation products with
read-across from the chemically-similar Alchisor CAL 123 as defined in
the `Read-Across Justification Document'. Where
toxicological data exist for Alchisor CAL 123, these are representative
of the Alchisor CAL 145 substance.
primary dermal irritation study was conducted in three albino rabbits
using test substance Alkenes, C11 -12, hydroformylation products,
distillation residues (CAS No: 90622 -27 -8). There was one intact test
site per animal. Each test site was treated with 0.5 mL of the undiluted
test substance and covered with a semi-permeable dressing. The test
substance was maintained in contact with the skin for 4 hours.
Observations for dermal irritation and defects were made at 1, 24, 48
and 72 hours after removal of the dressings. Erythema and edema were not
observed at any time throughout the study. No other signs of irritation
were observed during the study. One animal was found dead on Day 1 of
the study; the death was not considered related to the administration of
the test substance. A replacement animal was dosed. The test item was
found to be non-irritating to skin (according to EU criteria).
acute eye irritation study was conducted on three albino rabbits using
test substance alkenes, C11 -12, hydroformylation products, distillation
residues (CAS No: 90622 -27 -8). 0.1 mL of the test substance was placed
into the conjunctival sac of the right eye of each animal selected for
testing. All treated eyes were washed with room temperature deionized
water for one minute immediately after recording the 24-hour
observation. There were no positive effects exhibited in any eyes at 48
hours after treatment. Non-positive irritation was clear by 72 hours.
According to EU criteria the test item in this instance was reported to
be non-irritating to eyes.
findings do not warrant the classification of alkenes, C11 -12,
hydroformylation products, distillation residues (CAS No: 90622 -27 -8)
as skin or ocular irritants under the new Regulation (EC) 1272/2008 on
classification, labeling and packaging of substances and mixtures (CLP)
or under the Directive 67/518/EEC for dangerous substances and Directive
1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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