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Ecotoxicological information

Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Internationally accepted method, ECOSAR, EPA (USA)
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF)
GLP compliance:
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.199 mg/L
Basis for effect:
mortality
Remarks on result:
other: The estimated 96-h LC50 for fish is 0.199 mg/l (ECOSAR v1.00a, phenols class).
Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 96-h LC50 for fish is 0.199 mg/l (ECOSAR v1.00a, phenols class).
Executive summary:

The estimated 96-h LC50 for fish is 0.199 mg/l (ECOSAR v1.00a, phenols class).

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1999
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Remarks:
The tests was conducted based on OECD-GLP standard and OECD test guidelines. However, the Ministry of the Environment of Japan suggest confirmation of the results since the test was conducted in 1999 and some of the tests conducted before 2002 were performed using a dispersant.
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
not specified
GLP compliance:
yes
Analytical monitoring:
not specified
Vehicle:
not specified
Remarks:
The Ministry of the Environment in Japan suggest confirmation of results when considering the year of the test; it is possible that it was conducted with a dispersant.
Test organisms (species):
Oryzias latipes
Test type:
not specified
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Reference substance (positive control):
not specified
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1.1 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
mortality
Validity criteria fulfilled:
not specified
Conclusions:
The 96h-LC50 of BHT in Oryzias latipes was 1.1 mg/L.
Executive summary:

An acute toxicity to fish study was conducted by the Ministry of the Environment in Japan based on OECD GLP-standards and OECD guideline 203. The 96hour-LC50 of BHT in Oryzias latipes was 1.1 mg/L.

Description of key information

Estimated data: The estimated 96-h LC50 for fish is 0.199 mg/L (ECOSAR V1.00a. phenol class).

Experimental results: OECD guideline 203, GLP. The 96hour-LC50 of BHT in Oryzias latipes was 1.1 mg/L.

Key value for chemical safety assessment

LC50 for freshwater fish:
0.199 mg/L

Additional information

Key study: Estimated data: The estimated 96-h LC50 for fish is 0.199 mg/L (ECOSAR V1.00a. phenol class).

Suporting study: Experimental results: OECD guideline 203, GLP. The 96hour-LC50 of BHT in Oryzias latipes was 1.1 mg/L.