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Physical & Chemical properties

Dissociation constant

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Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No data available on test method.
Principles of method if other than guideline:
No data available on test method.
GLP compliance:
no
Dissociating properties:
yes
No.:
#1
pKa:
12.2
Remarks on result:
other: No data on temp.

pKa dissociation constant: 12.2.

Conclusions:
pKa dissociation constant: 12.2
Executive summary:

In a experimental study 2,6 -di-tert-butyl-4 -methylphenol (BHT) was found to have a pKa dissociation constant of 12.2.

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
not specified
Dissociating properties:
yes
No.:
#1
pKa:
12.07
Temp.:
37 °C
Conclusions:
The pKa of BHT at 37 º C was 12.07 determined by microelectrometric titration.
Executive summary:

The pKa of BHT was determined by microelectrometric titration in 50 % ethanol-water solution and corrected to pKa in water solution at 37 ºC. The pKa of BHT was 12.07.

Description of key information

In a study 2,6 -di-tert-butyl-4 -methylphenol (BHT) was found to have a pKa dissociation constant of 12.2.

The pKa of BHT was determined by microelectrometric titration in 50 % ethanol-water solution and corrected to pKa in water solution at 37 ºC. The pKa of BHT was 12.07.

Key value for chemical safety assessment

pKa at 20°C:
12.2

Additional information

Weight of evidence: Experimental results from published data.