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EC number: 204-881-4 | CAS number: 128-37-0
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No data available on test method.
- Principles of method if other than guideline:
- No data available on test method.
- GLP compliance:
- no
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 12.2
- Remarks on result:
- other: No data on temp.
- Conclusions:
- pKa dissociation constant: 12.2
- Executive summary:
In a experimental study 2,6 -di-tert-butyl-4 -methylphenol (BHT) was found to have a pKa dissociation constant of 12.2.
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 12.07
- Temp.:
- 37 °C
- Conclusions:
- The pKa of BHT at 37 º C was 12.07 determined by microelectrometric titration.
- Executive summary:
The pKa of BHT was determined by microelectrometric titration in 50 % ethanol-water solution and corrected to pKa in water solution at 37 ºC. The pKa of BHT was 12.07.
Referenceopen allclose all
pKa dissociation constant: 12.2.
Description of key information
In a study 2,6 -di-tert-butyl-4 -methylphenol (BHT) was found to have a pKa dissociation constant of 12.2.
The pKa of BHT was determined by microelectrometric titration in 50 % ethanol-water solution and corrected to pKa in water solution at 37 ºC. The pKa of BHT was 12.07.
Key value for chemical safety assessment
- pKa at 20°C:
- 12.2
Additional information
Weight of evidence: Experimental results from published data.
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