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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable, well-documented publication/study report which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Hazard assessment of butylated hydroxytoluene from urethane carpet cushions.
Author:
US Consumer Product Safety Commission
Year:
1998
Bibliographic source:
US Consumer Product Safety Commission, Bethesda, MD, USA
Reference Type:
study report
Title:
Unnamed
Year:
1998
Reference Type:
other: abstract
Title:
Sensory irritation in mice with carpet emission chemicals
Author:
Stadler, J., C.; et al.
Year:
1997
Bibliographic source:
The Toxicologist, Fundamental and Applied Toxicology, Abstracts of the 36th Annual Meeting, vol. 36, no. 1, part 2, March 97, 1670
Reference Type:
other: abstract
Title:
Adaptation of athreshold model for use in evaluation additivity of sensory irritants
Author:
Stadler, J., C.; et al.
Year:
1998
Bibliographic source:
SOT 1998 Annual Meeting, 1230

Materials and methods

Principles of method if other than guideline:
other: sensory irritation study of BHT
GLP compliance:
yes
Test type:
other: sensory irritation study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
BHT purity: >99.9%

Test animals

Species:
mouse
Strain:
Swiss Webster
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
head only
Vehicle:
other: unchanged (no vehicle)
Duration of exposure:
30 min
Concentrations:
4.54, 16.0, 32.1, 42.9, 66.6 and 82.6 ppm
No. of animals per sex per dose:
4

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
other: RD50
Effect level:
59.7 ppm
Based on:
test mat.
Exp. duration:
30 min
Remarks on result:
other: sensory irritation study

Any other information on results incl. tables

In this study for sensory irritation, 6 groups of 4 male Swiss Weber mice were exposed to BHT concentrations of 4.54, 16, 32, 42.9, 66.6 and 82.6 ml/m3 (head only exposure) for 30 minutes. The RD50 was calculated to be 59.7 ml/m3 (about 546 mg/m3). No indication of sensory irritations was observed at concentrations of 4.54 and 16 ml/m3 (about 41 and 146 mg/m3, respectively). The RD50 of 3.6 ml/m3 (Stadler and Lavoie 1997) reported in an earlier study by DuPont was thus not substantiated; the discrepancy was explained by problems in the analysis (recovery) in the DuPont study (US Consumer Product Safety Commission 1998).

Applicant's summary and conclusion

Executive summary:

In this study for sensory irritation, 6 groups of 4 male Swiss Weber mice were exposed to BHT concentrations of 4.54, 16, 32, 42.9, 66.6 and 82.6 ml/m3 (head only exposure) for 30 minutes. The RD50 was calculated to be 59.7 ml/m3 (about 546 mg/m3). No indication of sensory irritations was observed at concentrations of 4.54 and 16 ml/m3 (about 41 and 146 mg/m3, respectively) (US Consumer Product Safety Commission 1998).