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EC number: 700-071-4
CAS number: 932742-30-8
In a study conducted according to OECD
Guideline 414, groups of of 24 sperm-positive female Hsd. Brl. Han:
Wistar rats were treated with SIKA Hardener LI by oral administration
(gavage) daily at three dose levels of 0, 200, 400 and 1000 mg/kg bw/day
from day 5 up to and including day 19 post coitum. The treatment volume
was 4 mL/kg b wand PEG 400 was used as vehicle. The test item did not
cause death, adverse clinical signs and necropsy findings in the dose
groups. SIKA Hardener LI did not reveal any adverse effect on the
pregnancy, body weight, corrected body weight, and food consumption data
of the dams, on the gravid uterine weight, the intrauterine mortality of
the conceptuses, the number of viable fetuses and their sex
distribution, the fetal and placental weight. SIKA Hardener LI did not
increase the incidence of external and visceral and skeletal variations
and caused no external, visceral or skeletal malformations in the
fetuses. Based on these observations the No Observed Effect Level (NOEL)
was determined as follows:
NOEL maternal toxicity: 400 mg/kg bw/day
NOEL developmental toxicity: 1000 mg/kg
Based on these observations the No Observed
Adverse Effect Level (NOAEL) was determined as follows:
NOAEL maternal toxicity: 1000 mg/kg bw/day
NOAEL developmental toxicity: 1000 mg/kg
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