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EC number: 700-071-4
CAS number: 932742-30-8
The acute eye irritation study of the test
item 2,2-Dimethyl-3-lauroyloxy-propanal was performed in three New
Zealand White rabbits. The irritation effect of the test item was
evaluated according to the Draize method (OECD No.: 405, 2002). The test
item was placed into the conjunctival sac of the left eye of each
animal. The untreated right eye served as control. The treated eyes of
the test animals were not washed out following the instillation of 0.1
mL of the test item, which was administered in pure state, in a single
dose. The eyes were examined at 1, 24, 48, and 72 hours after the
application. One hour after the single application of
2,2-Dimethyl-3-lauroyloxy-propanal into the eyes of the rabbits slight
redness and moderately or severely increased discharge were observed in
the eyes of the test animals. Chemosis, corneal and iris alterations
were not found during the study. 24 hours after treatment in two animals
slight redness was observed and in one case slightly increased discharge
was noted. One animal became fully symptom-free by this time. 48 hours
after the treatment every animal was symptom-free. 72 hours after the
treatment the study was terminated, since no primary irritation symptoms
occurred. The general state and the behaviour of animals were normal
during the whole study. In conclusion, the test item
2,2-Dimethyl-3-lauroyloxy-propanal, applied to the rabbits' eye mucosa,
caused irritant effects, which can be evaluated as fully reversible
alterations within 48 h. According to the EU (DSD and GHS) criteria for
classification and labelling requirements for dangerous substances and
preparations the test item does not have to be classified and has no
obligatory labelling requirement for eye irritation.
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