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EC number: 700-071-4
CAS number: 932742-30-8
Based on the reactive nature of SIKA Hardener LI and its limited stability in water-based systems, bioaccumulation is not likely to occur. Orally consumed hardener is most rapidly hydrolysed to aldehyde and polyamine, with the reaction being acid catalysed. Even though the degradation products might be absorbed and become bioavailable, toxicity is low and bioconcentration rather unlikely. Absorbed or bioavailable degradation products are probably excreted, either in original form or further metabolised, prior to elimination via urine or bile.
Hardener LI belongs to a class of polyaldimine compounds used as
hardeners for polyurethane moisture hardening preparations. The
preparations are used as adhesive and sealant in the production of
transport vehicle modules. On contact with water, the hardening process
is initiated and the hardener rapidly hydrolysed. Hydrolysis products
formed are the aldehyde 2,2-dimethyl-3-lauroyloxy-propanal and
corresponding polyamine. The hardener and polyurethane mass react and
become chemically bound in the polymer matrix, irreversibly integrating
the amine component and the polyamine and to some extend the aldehyde.
Due to the use of the compound, SIKA Hardener LI has a very limited
stability in water, as it needs to rapidly react upon contact with
water. Thus, determination of its partition coefficient or water
solubility is technically not feasible. The theoretical partition
coefficient and water solubility ranges were calculated, taking the
varying oligomere chain lengths into account.
on molecular structure and physical-chemical properties, bioaccumulation
of SIKA Hardener LI is not likely to occur. Dermal and inhalation uptake
can be practically exclued. Orally consumed hardener is very fast
hydrolysed to aldehyde and polyamine, in the acid environment of the
stomach. Even though the degradation products might be absorbed and
become bioavailable, toxicity is low and bioconcentration rather
unlikely. Absorbed or bioavailable degradation products are probably
excreted, either in original form or further metabolised, prior to
elimination via urine or bile. Formation of toxic metabolites is
unlikely, based on the results of the subacute toxicity study and two in
vitro studies using isolated S9 fractions. However, a subchronic oral
toxicity study indicated toxicity as a test item related effect was
observed at 1000 mg/kg bw (changes in spleen weights in female rats),
resulting in a NOAEL of 300 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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