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EC number: 213-254-4
CAS number: 932-64-9
Moderate to severe testicular hypoplasia was observed in all male rats
in the 1000 mg/kg/day dose group. The finding was characterized by
interstitial degeneration and loss of spermatogenic epithelium in the
seminiferous tubules with practically no cells or spermatogenesis in the
spermatic tubules except for some remnant Sertoli cells on the basement
membrane. Corresponding aspermia was present in the epididymides of
these high-dose males. At lower doses, these lesions were less frequent
and severe and consisted of interstitial degeneration rather than
tubular degeneration. Table 1 below shows the incidence and severity of
the lesions as evaluated by Wallace, 2011.
Table 1 Incidence and Severity of
Testicular Lesions in Male Rats
Minimal Tubular Degeneration/Atrophy
Mild Tubular Degeneration/Atrophy
Moderate Tubular Degeneration/Atrophy
Severe Tubular Degeneration/Atrophy
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