Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-254-4
CAS number: 932-64-9
Moderate to severe testicular hypoplasia was observed in all male rats
in the 1000 mg/kg/day dose group. The finding was characterized by
interstitial degeneration and loss of spermatogenic epithelium in the
seminiferous tubules with practically no cells or spermatogenesis in the
spermatic tubules except for some remnant Sertoli cells on the basement
membrane. Corresponding aspermia was present in the epididymides of
these high-dose males. At lower doses, these lesions were less frequent
and severe and consisted of interstitial degeneration rather than
tubular degeneration. Table 1 below shows the incidence and severity of
the lesions as evaluated by Wallace, 2011.
Table 1 Incidence and Severity of
Testicular Lesions in Male Rats
Minimal Tubular Degeneration/Atrophy
Mild Tubular Degeneration/Atrophy
Moderate Tubular Degeneration/Atrophy
Severe Tubular Degeneration/Atrophy
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Questo sito web si avvale di cookie affinché possiate usufruire della migliore esperienza sui nostri siti web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again