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EC number: 213-254-4
CAS number: 932-64-9
According to the Biotechnology Research Institute of NRC, 2010, the 96h
EC50 was found to be 2323.7 mg/L.
The toxicity to aquatic algae was also examined by AnalyCen Ecotox AS.
The72 hours EC50 value for the test substance NTO, Nitrotriazolone was
found to be 113 mg/L.
According to Haley Mark V.,Kuperman Roman G., Checkai Ronald T. (Aquatic
Toxicity of 3-Nitro-l,2,4-triazol-5-one ), 96h NOEC for the test
substance to Scenedesmus capricornutum is 1375 mg/L; 96h LOEC for the
test substance to Scenedesmus capricornutum is 2680 mg/L.
The calculation by EPIWIN was showing EC50 of 1329.272 mg/L after 96
The toxicity of NTO to aquatic plants was assessed (Covance, 2020)
according to OECD test guideline 201 and EC method C.3. Cultures of
Raphidocelis subcapitata (formerly known as Pseudokirchneriella
subcapitata) were exposed to NTO at nominal concentrations of 1, 3.2,
10, 32 and 100 mg/L for 72 hours; a supplementary 100 mg/L concentration
level. adjusted to approximately neutral pH prior to incubation was also
In the groups without pH adjustment the 72 -hour EC50 was 19 mg/L in
terms of growth rate and 14 mg/L in terms of yield. The NOEC was 10
mg/L in terms of both rate and yield.
In the pH-adjusted group, the EC50 in terms of growth rate and yield was
> 100 mg/L. The NOEC in terms of growth rate was 100 mg/L. A NOEC
could not be calculated in terms of yeild as a statistically significant
difference between the 100 mg/L level and the control was observed.
It was observed that the test material had caused a significant decrease
in the pH in the unadjusted groups; it is considered that this may be
representative of the situation which may arise if the substance were
released into a closed aquatic system with no significant buffering
capacity and no dilution over time. It is considered that this
situation is unlikely to be representative of actual environmental
release; actual environmental release into fresh or marine water would
typically be associated with significant dilution and / or pH buffering
from the aquatic environment. On this basis the results of the
pH-adjusted test group will be used for the purposes of hazard
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