Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study run to a detailed method. None GLP.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1985

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Twenty-five young adult (≈ 68 days) Sprague-Dawley male rats were used in the 5 g/kg test group. After the treatment, all animals were observed daily for 30 days for aberrant physiological and behavioral responses.
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dihydro-5-nitro-3H-1,2,4-triazol-3-one
EC Number:
213-254-4
EC Name:
1,2-dihydro-5-nitro-3H-1,2,4-triazol-3-one
Cas Number:
932-64-9
Molecular formula:
C2H2N4O3
IUPAC Name:
1,2-dihydro-5-nitro-3H-1,2,4-triazol-3-one
Test material form:
solid: crystalline
Details on test material:
- Name of test material : 3-NITRO-1 ,2,4-TRIAZOL-5-0NE (NTO)
- Substance type: energetic explosive
- Physical state: light green to white crystalline solid with no odor
- Purity ca.99%
Specific details on test material used for the study:
Batch No.: not specified
Purity: not specified

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: ≈ 68 days
- Weight at study initiation: 290-330 g

No additonal data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 500 mg/cc of corn oil
- Justification for choice of vehicle: This vehicle was used to solubilize the mixture in an innocuous medium.

No additional data
Doses:
5 g/kg
No. of animals per sex per dose:
25 male rats per dose
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 30 days
- Frequency of observations and weighing: After treatment , all animals were observed daily for 30 days for aberrant physiological and behavioral responses.

No additional data
Statistics:
None stated

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality
Clinical signs:
other: In general, all rat behavioral, clinical, and physiological responses after administration appeared normal.
Gross pathology:
No information provided
Other findings:
No information provided

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 value for NTO to Sprague-Dawley rat was greater than 5 g/kg.