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EC number: 945-888-9
CAS number: -
In a primary eye irritation study
conducted according to OECD guideline 492, 50 mg of zirconium
oxide, hafnium and ytterbium doped (purity >99.5%) was
applied topically on EpiOcular tissue, a reconstituted three-dimensional
human corneal epithelium model for 6 h and a post-treatment period of 18
h compared to that of the concurrent negative control. Irritation was
scored by the method of mean relative tissue viability.
The mean relative tissue viability
(% negative control) was > 60% (60.2%). As the results were within the
borderline values (60 ± 5%), a second experiment was performed to
confirm the first results. The mean relative tissue viability
(% negative control) of the second experiment was > 60% (99.2%) and the
test item did not show irritant effects. Based on these results, the
test item can be classified as a non-irritant according to the UN GHS
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