Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented publication/study report which meets basic scientific principles
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data - List V
Author:
Smyth H F et al.
Year:
1954
Bibliographic source:
Archives of Industrial Hygiene and Occupational Medicine (1954), 10, 61-8

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
Deviations:
yes
GLP compliance:
no
Remarks:
Study performed before implementation of GLP
Test type:
fixed concentration procedure
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Remarks on duration:
see "Concentrations"
Concentrations:
500 ppm for 4 h
concentrated vapour (defined as nearly saturated) for 1 h
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 500 ppm
Exp. duration:
4 h
Mortality:
2/6 at 500 ppm for 4 h
none at 1 h concentrated vapour
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Executive summary:

In an acute inhalation toxicity study, groups of 6 young adult male Carworth-Wistar rats were exposed by inhalation route to of styrene oxide for 4 hours at concentrations of  500 ppm  mg/L.  Animals then were observed for 14 days.

LC50Males > 0.5 ml/L for 4 h

Styrene Oxide is classified as being of LOW Toxicity based on males.