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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Experimental Carcinogenicity and Acute Toxicity of Representative Epoxides
Author:
Weil C S et al.
Year:
1963
Bibliographic source:
Amer Industr Hyg Ass J 24:305-325.

Materials and methods

Principles of method if other than guideline:
Sensitization of guinea pigs was determined by a technique consisting of eight intracutaneous injections (three per week on alternate days) of 0.1 ml of the diluted epoxy materials. A three-week icubation period was followed by a challenge dose and examinations for possible sensitization reactions were made 24 and 48 hours thereafter.
GLP compliance:
no
Remarks:
Study performed before implementation of GLP
Type of study:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
intradermal
Vehicle:
no data
Concentration / amount:
no data
Challengeopen allclose all
Route:
intradermal
Vehicle:
no data
Concentration / amount:
no data
No. of animals per dose:
11
Positive control substance(s):
not specified

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information