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EC number: 607-759-2
CAS number: 25618-55-7
Detailed results (irritation scores):
Time post appl.
30 -60 min
The primary skin irritation potential of the test item was investigated
according to OECD test guideline no. 404. The test item was applied by
semi-occlusive application of 0.5 mL to the intact flank of each of
three New Zealand White rabbits. The duration of treatment was four
hours. The scoring of skin reactions was performed 30 -60 minutes, 24,
48 and 72 hours after removal of the patch.
The mean score was calculated across 3 scoring times (24, 48 and 72
hours after patch removal) for each animal for erythema/eschar grades
and for oedema grades, separately. The mean erythema/eschar score of the
three animals was 0.00 and the mean oedema score was 0.00 for all
The application of the test item to the skin resulted in no signs of
irritation. The test item is considered to be “not irritating” to rabbit
With reference the reported scores and the absence of any signs of
irritation during the whole study period the test item does not need to
be classified as irritant to the skin according to the criteria laid
down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU
Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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