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EC number: 607-759-2
CAS number: 25618-55-7
The substance is readily biodegradable. In addition, the log Kow
is below 3 and the substance has no cationic properties, a low
adsorption potential is indicated. Therefore, binding to sewage sludge
is unlikely and as a consequence a transfer to the soil compartment is
not expected. Therefore, no tests on terrestrial organisms are provided.
Furthermore, considering all available ecotoxicological data from
the substance itself and read across substances combined in an expert
statement as presented below the substance is unlikely to pose a risk to
terrestrial organisms in general.
Having regard to the general rules for grouping of substances and
read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC)
No 1907/2006 whereby physicochemical, toxicological and ecotoxicological
properties may be predicted from data for reference substance(s) by
interpolation to other substances on the basis of structural similarity,
the two substances listed in Table 1 are selected as reference
substances and the available endpoint information is used to predict the
same endpoints for 1,2,3-Propanetriol, homopolymer (CAS 25618-55-7).
A read across from the source substances in order to assess the
environmental fate and aquatic toxicity of 1,2,3-Propanetriol,
homopolymer (CAS 25618-55-7) is considered valid, since the reference
substances represent the main components of the target substance. The
only differences are i) the slightly different proportional composition
of these components and ii) the absence of mono-glycerol, a main
component of the target substance but not part of reference substance 1.
Therefore, data for mono-glycerol (reference substance 2), although
listed in Annex V of Regulation (EC) No. 1907/2006 and thus exempted
from registration, are considered additionally. Based on the fact that
the components of the reference substances and the target substance are
identical the functional groups (hydroxyl groups) and the metabolites
are expected to be identical as well.
Table 1: Data for the target substance and the two considered
915-741-3 (List No)
Reaction mass of 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol,3-(2,3-dihydroxypropoxy)propane-1,2-diol,3-[3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy]propane-1,2-diol
92.09 – 314.34
166.18 – 314.34
mono-glycerol: 33.3 %
di-glycerol: 28.49 %
tri-glycerol: 15.48 %
tetra-glycerol: 8.33 %
di-glycerol: 15-35 %
tri-glycerol: 35-55 %
tetra-glycerol 10-25 %
> 550 g/L
> 1000 g/L
> -3.9 < -3.3
≤ 0.047 Pa at 20 °C
Experimental result:0.00000673 Pa at 20 °C
~ 0.1 Pa at 20 °C
Aquatic ecotoxicity data
Short-term aquatic toxicity data for the reference substances are
available for all trophic levels. Long-term data is available for
aquatic algae. Based on the experimental data, it can be considered that
1,2,3-Propanetriol, homopolymer (CAS 25618-55-7) exhibits no toxicity to
aquatic organisms up to the highest tested concentration of 500 mg/L
(fish) and 1000 mg/L (daphnia, algae), respectively. The substance is
thus not expected to pose a risk to terrestrial organisms as well.
The low log Kow value of -2indicates only a low bioaccumulation
potential of 1,2,3-Propanetriol, homopolymer (CAS 25618-55-7). If
ingested and absorbed, the mono-glycerol component is expected to be
rapidly metabolised via cleavage of the ether bond as shown by Saunders
& Dawson (1962) and Haessler & Isselbacher (1963) in rats and hamster.
In contrast the polyglycerols are not expected to be catabolized but
excreted rapidly into the urine after absorption as shown, for example,
for triglycerol and polyglycerol (C10) by Michael and Coots (1971).
1,2,3-Propanetriol, homopolymer (CAS 25618-55-7) is unlikely to
pose a risk for terrestrial organisms based on a) the lack of direct
exposure based on identified uses, b) lack of indirect exposure due to
ready biodegradability and low log Kow and thus low adsorption potential
and c) rapid excretion and metabolism via common pathways, leading to
expected low bioaccumulation potential and low toxicity.
ECHA (European Chemicals Agency). 2012b.
Guidance on information requirements and chemical safety assessment.
Chapter R7.b: Endpoint specific guidance, version 1.2 (November 2012),
Haessler HA, Isselbacher KJ. 1963. The
metabolism of glycerol by intestinal mucosa. Biochem Biophys Acta 73(3):
Michael WR, Coots RH. 1971. Metabolism
of polyglycerol and polyglycerol esters. Toxicol Appl Pharmacol 20(3):
Saunders DR, Dawson AM. 1962. Studies on
the metabolism of glycerol by the small intestine in vitro and in
vivo.Biochem J 82(3): 477 -483
e in vitro and in vivo. Biochem J 82(3):
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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