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EC number: 607-759-2
CAS number: 25618-55-7
The primary eye irritation potential of the test item was investigated
according to OECD test guideline no. 405. The test item was applied by
instillation of 0.1 mL into the left eye of each of three New Zealand
White rabbits. Scoring of irritation effects was performed approximately
1, 24, 48 and 72 hours after test item instillation.
The mean score was calculated across 3 scoring times (24, 48 and 72
hours after instillation) for each animal for corneal opacity, iris,
redness and chemosis of the conjunctivae, separately. All individual
mean scores were 0.00 for all three animals.
The instillation of test item into the eye resulted in mild, early-onset
and transient ocular changes, such as reddening of the conjunctivae,
discharge and chemosis, which were mostly present at the 1-hour reading.
24 hours after the treatment, no signs of eye irritation were observed
in the conjunctivae of the animals. Furthermore, no abnormal findings
were observed in the cornea or iris of any animal at any of the
examinations. No corrosion was observed at any of the measuring
intervals. No staining of the treated eyes by the test item was observed
and no clinical signs were observed.
Thus, the test item did not induce significant or irreversible damage to
the rabbit eye.
With reference to the reported scores and observations the test item
does not need to be classified as irritant to the rabbit eye according
to the criteria laid down in the EU Dangerous Substances Directive
(67/548/EEC) and in the EU Classification Labelling and Packaging
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