Registration Dossier
Registration Dossier
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EC number: 607-759-2 | CAS number: 25618-55-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The acute oral toxicity of the test item was investigated in 5 female and 5 male rats using purified water as vehicle. The study was performed according to OECD test guideline 401 and followed the principles of GLP. All animals were administered the test compound by single-dose gavage at a dose-level of 2000 mg/kg body weight. The observation period was 14 days. No deaths occurred during the study. Clinical signs of intoxication were also not observed during the course of the study. Body weight development was normal and within the range commonly recorded for this strain and age. At necropsy no macroscopic findings were recorded. Based on the findings of this limit-test the median lethal dosage (LD50) of the test item in male/female rats is greater than 2000 mg/kg body weight.
The acute dermal toxicity of glycerin was tested in a method equivalent to the OECD 402 guideline. No adverse effects were observed. The same can be expected for polyglycerin.
Justification for selection of acute toxicity – oral endpoint
Guideline study performed according to GLP
Justification for classification or non-classification
Based on the results from an available guideline study, the registered substance is not subject to labelling and classification requirements with regard to the oral and dermal route of exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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