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EC number: 283-829-2
CAS number: 84731-70-4
For hazard considerations, it is considered not necessary to conduct a
carcinogenicity study for this substance.
According to Regulation (EC) No. 1907/2006, Annex X, Section 8.9.1,
Column 2: A carcinogenicity study may be required if:
1) the substance has a widespread dispersive use or there is evidence of
frequent or long-term human exposure, and
2) the substance is classified as germ cell mutagen category 2 or there
is evidence from the repeated dose study(ies) that the substance is able
to induce hyperplasia and/or pre-neoplastic lesions.
For this substance, the substance is not classified as a germ cell
mutagen. All the germ cell mutation studies give negative results, and
in repeated dose studies, although it showed higher incidence of
follicular cells hypertrophy in thyroid gland at high dose (1000 mg/kg)
in 28-day study, it did not show that the substance is able to induce
hyperplasia and/or pre-neoplastic lesions in 90-day study.
Hence for hazard considerations, it is not considered necessary to
conduct a carcinogenicity study for this substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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