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EC number: 283-829-2
CAS number: 84731-70-4
Not sensitising to skin (OECD 406)
Clinical signs and mortality
No treatment-related clinical signs or death were found during the
A slight but statistically significant decrease in weight gains was
observed in group T2 compared to those of the group V2. This was
considered to be due to chance as there were no associated clinical
Observation of application sites
Approximately 48 and 72 h after the start of the challenge
application (24 and 48 h from the patch removal) the skin reaction was
observed. The average skin reaction scores in the group T1, V1 , T2 and
V2 at 48 h were 0.0, 0.0, 2.85 and 0.0 respectively. The sensitisation
rates at the same time point were 0, 0, 100 and 0 & respectively. Thus,
the skin sensitivity of the test substance was considered weak (Grade 1)
while that of the positive control item was extreme (Grade V). The
average skin reaction scores in the group T1, V1, T2 and V2 at 72 hours
were 0.0, 0.0, 2.55 and 0.0 respectively. The sensitisation rates at the
same time point were 0, 0, 100, 0 %, respectively.
Control results and validity
In a guinea pig maximisation test to OECD guideline 406, the substance
was found not to be sensitising to skin.
The substance should not be classified as a skin sensitiser because the
available test data do not meet the criteria set out in Regulation (EC)
No data are available for respiratory sensitisation, although this is
not a concern given the very low vapour pressure and the lack of
sensitisation shown in a dermal sensitisation study.
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