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EC number: 283-829-2
CAS number: 84731-70-4
substance is a clear colourless liquid and the molecular weight is 396.6
g/mol. The low vapour pressure value (7.45 x 10-4Pa
at 50°C; Jeong, 2009) shows that the substance is non volatile therefore
inhalation is not a significant route of exposure. The substance has a
high log octanol/water partition coefficient value (Log10Pow8.84
Jeong, 2009) and low water solubility (47 μg/L; Jeong, 2009).The
available repeated dose/reproductive screening study showed evidence of
absorption and metabolism but did not show any evidence of excretion
item is non-mutagenic in bacteria (Kim, 2009 c), non-clastogenic in
mammaliancells in vitro(Kim, 2009 a) in either the absence or
presence of an auxiliary metabolizing system (Morris, 2012) or
non-genotoxic in the mouse (Kim, 2009 b). The test item is not a dermal
irritant or a skin sensitizer (Bae, 2009 a; Bae, 2009 c; Pooles, 2010).
In accordance with Annex VIII (point 8.8) of Regulation (EC) No
1907/2006 (REACH), a paper-based toxicokinetic assessment has been
conducted for the substance, DEHCH (Di 2-ethylhexyl
cyclohexane-1,4-dicarboxylate). Summaries of studies were reviewed by a
qualified toxicologist with a view to fulfilling the requirements of
Annex VIII, point 8.8 of REACH. The assessment of the likely
toxicokinetic behaviour of the substance was provided to the extent that
can be derived from the relevant available information at the time of
the assessment. The assessment is based on the Guidance on information
requirements and chemical safety assessment Chapter R.7c: Endpoint
specific guidance (ECHA, November 2012).
the repeated dose/reproductive screening study in rats showed evidence
to support the gastric absorption of the test item (Dunster, 2010). The
relatively small molecular size of the substance should also allow
absorption through passive diffusion. This is supported by the
lipophilic nature of the substance (log10Pow8.84,
Jeong, 2009). This would suggest that the gastro-intestinal tract
provides a route of absorption, following oral administration, before
entering the circulatory system via the blood. Limited absorption may
also take place via the skin due to the relatively small molecular size.
The low vapour pressure value (7.45 x 10-4Pa
at 50°C; Jeong, 2009) shows that the substance is not available as a
vapour therefore inhalation is not a significant route of exposure.
distribution is evident from the repeated dose/reproductive screening
study (Dunster, 2010) as a result of the organ changes observed. The
lack of evidence to suggest the test item is a skin sensitizer suggests
that it does not bind to carrier proteins in the circulatory system
(Bae, 2009 c). Once absorbed, the substance may potentially accumulate
in the adipose tissue due to the high log octanol/water partition
coefficient value (Log10Pow8.84,
of the repeated dose/reproductive screening study showed the evidence of
an adaptive response in the liver and thyroids in rats (Dunster, 2010);
which is normally associated with enhanced metabolism. The results of
the genotoxicity assays have shown that genotoxicity is neither enhanced
nor diminished in the presence of the S9 metabolising systems (Kim, 2009
a; Kim, 2009 c).
There is no
evidence to indicate the route of excretion but poorly water-soluble
products are not favourable for urinary excretion and therefore biliary
excretion may well be a significant route for this material. As there is
evidence of hepatic metabolism this does not, however, rule out urinary
excretion. The main reason for xenobiotic metabolism is to render the
product more water soluble thereby facilitating urinary excretion. Any
test item that is not absorbed will be excreted in the faeces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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