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EC number: 283-829-2
CAS number: 84731-70-4
Endpoint waived due to the low bioaccumulation potential of the
substance in aquatic organisms and absence of toxicity in mammalian
According to Regulation (EC) No. 1907/2006, Annex X, Section 9.6.1
Column 2: Any need for testing should be carefully considered taking
into account the large mammalian dataset that is usually available at
this tonnage level.
This assessment criteria are expanded in ECHA Guidance on Information
Requirements and Chemical Safety Assessment, Chapter R.7c: Endpoint
specific guidance, Version 3.0, June 2017, Section R.18.104.22.168
Preliminary considerations. This section lists conditions where No
avian toxicity data are available that could lead to avian studies being
1) Potential to contaminate food chains: Bioaccumulation potential of
the substance is however very low. A bioaccumulation study has shown
the mean BCF to be 9. The substance was shown not to significantly
accumulate in fish tissue and was observed to be eliminated from the
fish tissues over a 25 day depuration period. Based on this information
the biological half-life of the test item is considered to be between 6
to 25 days.
2) Evidence of toxicity in mammalian repeat dose or reproductive
toxicity studies: The substance has a large mammalian toxicity dataset
showing low toxicity and no triggering any hazard classifications.
In conclusion, due to the low bioaccumulation potential of the substance
in aquatic organisms secondary poisoning is not considered to be a route
of exposure that has to be further assessed for this substance.
Furthermore, the substance has a large mammalian dataset already,
showing low toxicity. Therefore the long-term or reproductive toxicity
to birds endpoint is waived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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