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EC number: 283-829-2
CAS number: 84731-70-4
28 d oral toxicity NOAEL: 100 mg/kgw bw/d (males), 300 mg/kg bw/d
(females) (OECD 422).
90 d oral NOAEL: ≥ 1000 mg/kg bw/d (OECD 408)
Repeat oral toxicity
In the 28 day repeat dose study, the NOAELs were 100 mg/kg bw for males
and 300 mg/kg bw for females. In the study the following effects were
recorded and considered to be treatment-related:
However, in the 90 day repeat dose study, the NOAEL was ≥ 1000 mg/kg bw.
The longer term value is preferred for calculating the DNEL. In the
absence of similar findings, it can be concluded that the attribution of
the findings of treatment effects in the 28 day study were adaptive
changes not associated with permanent structural alterations or
Repeat inhalation toxicity
Inhalation of the substance is unlikely due to the extremely low vapour
pressure. Given this, and the absence of adverse findings in the 90 day
repeat dose oral study, inhalation toxicity is not of concern. Testing
for this endpoint has been waived.
Repeat dermal toxicity
There are repeat oral studies (28 day and 90 day) available, and no
adverse findings observed in 90 day repeat oral study, dermal toxicity
is not of concern. Testing for this endpoint has been waived.
The no adverse-effect level of the test item in the 90 day oral study
was determined to be ≥1000 mg/kg bw. There was no evidence of specific
organ toxicity in the study and therefore classification is not
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