Registration Dossier
Registration Dossier
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EC number: 433-400-2 | CAS number: 4245-76-5
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis of CA2342 at approximately 80 mg/L (exact concentrations are known) was studied in the dark at 50ºC in sterile aqueous buffered solutions at pH 3.8 (citrate buffer), pH 7 (phosphate buffer) and pH 9 (borax buffer) for 5 days. The experiment was conducted in accordance with the EEC method C.7 and the OECD Guideline 111, and in compliance with Good Laboratory Pratice (GLP) in Switzerland, Procedures and Principles, March 1986, issued by the Federal Department of the Interior and the Intercantonal Office for the Control of Medicaments, Switzerland. These procedures are based on the OECD Principles of Good Laboratory Practice of the OECD Council [C (81) 30 (Final)] concerning Mutual Acceptance of Data in the Assessment of Chemicals.
Samples were analysed at 0h, 2 -4h, 2d, and 5d after taking aliquots from the hydrolysis solution by HPLC using external standard calibration.
After five days at 50 °C less than 10 % of the test substance had hydrolysed at any of th einvestigates pH values. Therefore, in accordance with the test methods used, the half-life (lives)/DT50 (50% decline times) of the pure intermediate may be estimated from the preliminary test to be > 1 year at 25 °C for all three pH values.
This study is classified acceptable and satisfies the guideline requirement for hydrolysis study.
Key value for chemical safety assessment
Additional information
Guideline Test Type |
Species |
Half life |
Reference |
Reliability |
EU C.7 OECD 111 |
Not applicable |
pH 3.8 (25 °C) > 1 yr pH 7 (25 °C) > 1 yr pH 9.1 (25 °C) > 1 yr |
Stulz, J., Novartis Crop Protection, 1999 |
Reliable without restriction |
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