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Toxicological information

Endpoint summary

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Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

A guinea pig maximisation test was initiated to determine sensitising properties of CA 2342 A after challenge exposure by skin contact. The procedure of Magnusson and Kligman for adjuvant tests was followed. Epidermal challenge of 10 male and 10 female guinea pigs (test groups) resulted in no positive responses in all guinea pigs after 24 hours and 48 hours, corresponding to a sensitisation rate of 0%. No irritant skin reactions were recorded for control animals. Based on these results, classification of CA 2342 A (Intermediate of CGA 293343) as to its sensitising properties is not required. A LLNA assay was not performed (see comments in study report "LLNA waived").

Migrated from Short description of key information:
Based on the sensitization rate of 0%, which is below the threshold of significance (i.e. below 30%) set in Commission Directive 93/21/EEC (18th
adaptation to technical progress of Council Directive 67/548/EEC), classification of CA 2342 A as to its sensitising properties is not required.

Justification for classification or non-classification