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Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

The ready biodegradabilty of CA 2342 A was determined in a 28 day DOC Die-Away Test, according to GLP Guideline OECD 301A, under aerobic conditions in indirect daylight at room temperature (23 -24 ºC). The experiment was conducted in compliance with Good Laboratory Pratice (GLP) in Switzerland, Procedures and Principles, March 1986, issued by the Federal Department of the interior and the Intercantonal Office for the Control of Medicaments, Switzerland. 
The test substance and the reference substance were tested in a concentration of 38.9 and 36.6 mg/l DOC, respectively.
The test system consisted of a mixture of polyvalent bacteria collected from the aeration tank of a domestic sewage treatment plant. The bacteria concentration was 30 mg/l suspended solids.
The degradation was followed by DOC analysis at frequent intervals over a period of 28 days. Abiotic and inhibition samples served as controls. The degree of biodegaradation was calculated by expressing the concentration of DOC removed (corrected by the blank inoculum control) as a percentage of the concentration initially added. (DOC determination: TOC/DOC Analyzer SHIMADZU TOC 500). The degree of primary biodegradation could also be calculated from supplemental chemical analysis made at the beginning and at the end of the test.
The mean value of the biodegradation of CA 2342 A after 28 days was 0 %. The Biodegradation of the reference substance after 28 days was 96 %.
On the basis of the present study CA 2342 A (Intermediate to CGA 293343) was not readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed

Additional information

Guideline Test Type


Interpretation of results



OECD 301 A

Not applicable

Not readily biodegradable

Ciba-Geigy Ltd., Dietschv, A, 1996

Reliable without restriction