Registration Dossier
Registration Dossier
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EC number: 200-554-5 | CAS number: 63-05-8
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 to 21 Oct 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Temp.:
- 30 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- The vapour pressure of Adrost-4-ene-3, 17-dione is 0.00000098 Pa at 20°C.
- Executive summary:
The vapour pressure of the substance of 9.8*10-7 Pa at 20°C was calculated using a semi logarithmic linear regression based on the Antoine equation (with 95% confidence interval). The temperature dependence of the vapour pressure was determined with the Knudsen effusion method using a vapour pressure balance in the temperature range of 75 -110 °C.
Reference
The vapour pressure was calculated using a semi logarithmic linear regression based on the Antoine equation (with 95 % confidence interval).
Validity criteria for the measurement of the vapour pressure:
| Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
| The vapour pressure should be determined for at least two temperatures. Three or more are preferred in the range 0 to 50 °C, in order to check the linearity of the vapour pressure curve. | Three temperatures (20, 25 and 30 °C) are measured. | Yes |
| A log p versus 1 /T curve should be stated. | Stated in report. | Yes |
| An estimate of the vapour pressure at 20 or 25 °C should be stated. | Stated in report. | Yes |
Description of key information
The vapour pressure of Androst-4-ene-3, 17-dione is 9.8*10 E-7 Pa at 20 °C.
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
Androst-4-ene-3,17-dione is to be considered as non volatile in aqueous solution.
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