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EC number: 208-253-0
CAS number: 518-47-8
patients with ocular problems are exposed to fluorescein in topical
form, during routine ocular examination. A case of a 51-year-old woman
who developed an anaphylactic reaction when she was administered
fluorescein sodium 2% eye drops after cataract surgery is reported.
51-year-old English woman attended the Oxford Eye Hospital for a
postoperative check-up two weeks after uneventful phacoemulsification
cataract surgery that was performed under topical anaesthesia. As part
of the ophthalmic examination, fluorescein 2% eye drops (Bausch and Lomb
Minims®) were administered topically into her operated eye in order to
check the corneal wound integrity and measure the intraocular pressure.
No other eye drops were instilled into her eye during her outpatient
visit. Within 30 seconds of topical fluorescein administration, she
developed acute dyspnoea, wheezing and tachycardia. Well-versed with the
symptoms of the onset of anaphylaxis, she administered 0.6 mg
intramuscular adrenaline from her auto-injector (EpiPen®). Venous access
was obtained and the patient was given intravenous chlorpheniramine and
oral prednisolone. Despite a good initial response, she deteriorated
acutely within 30 minutes, with tongue swelling, airway obstruction, and
subsequent loss of consciousness. Following appropriate resuscitation,
she was transferred for further observation to the intensive care unit.
She was discharged from our hospital after 48 hours.
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