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EC number: 208-253-0
CAS number: 518-47-8
In a Teratogenicity study,New Zealand
female Rabbits were treated with Fluorescein sodium in the concentration
of 2241.4 mg/kg intravenouslly in 10% water solution (Funduscein) on day
5,6 and 8 day after copulation. No effect was observed on survival
and no abortion or miscarriages were observed in treated rats as
compared to control. No effect on live-born offspring and stillbirth
were observed in treated rabbits as compared to control. No effect on
live-born offspring was observed. At 4 week, 14 offspring (19%) from
four mothers subsequently died. The observed effects were due to poor
mothers and not due to treatment. One stillbirth and all other
offspring were normal and no delayed appearances of birth defects were
observed in offspring as compared to control. In addition, no gross
pathological and histopathological changes were observed in offspring of
treated rabbits as compared to control. Therefore, NOAEL was considered
to be 2241.4 mg/kg for F0 and F1 generation when New Zealand female
Rabbits were treated with Fluorescein sodium intravenouslly in 10% water
solution (Funduscein) on day 5, 6 and 8 day and day 13, 15 and 16 day
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