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EC number: 208-253-0
CAS number: 518-47-8
Mean maternal body weights
changesfor rats given D & (" Yellow No. 8 by gavage on days 6 -19 of
Day of gestation
No. of foetuses (no. of litters)
249 ± I3.7
271 ± 14.4
263 ± 12.2
278 ± 15.9
292 ± 17.5
296 ± 16.1
320 ± 18.9
323 ± 20.4
300 ± 30.7
In a teratogenic potential study,
Sprague-Dawley Female rats were treatedw with D & C Yellow No. 8 in the
concentration of 0, 100, 500 and 1500mg/kg body weight orally by gavage.
Six rats died at 1500 mg/kg bw as compared to control. Orange
discoloration of the urine was observed in 100, 500 and 1500 mg/kg bw
treated rats and Slight decrease in body weight gain were observed in
1500 mg/kg bw treated rats as compared to control. Green discoloration
of the amniotic fluid was observed in 1, 10 and 16 rats in the 100, 500
and 1500 mg/kg/day treated rats as compared to control. But, no effect
on dams with viable foetuses, viable foetuses/dam, post-implantation
loss, total implantations, corpora lutea and number of litters with
malformations were examined in treated rats as compared to control. In
addition, No significant effect on Foetal sex ratio, foetal body weight,
gross pathology and histopathology were observed. Therefore, NOAEL was
considered to be 1500 mg/kg bw when Sprague-Dawley Female rats were
treated with D & C Yellow No. 8 orally by gavage from day 6-19 of
Based on the observations these doses
did not result in evidence of maternal toxicity or adverse effects on
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