Registration Dossier

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

LC50 (96 hrs, Medaka-Oryzias latipes)_OECD guideline 203 (Fish, Acute Toxicity Test) > 0.306 mg/L ( geom. mean of measured concentration) Limit test.
Since this concentration was considered to be around solubility of the substance,
LC50 96h (nominal) : > 100 mg/L

Key value for chemical safety assessment

LC50 for freshwater fish:
100 mg/L

Additional information

The GLP study was conducted as a limit test in order to confirm the effect of the test item on the test organisms at the concentration around the solubility of the test item in dilution water. Although all measured concentrations of the test item in the test solution at the preparation during the exposure were greater than the solubility measured concurrently with the definitive study, they decreased at the 24 hours after the preparation. The reason why the concentration of the test item in the test solution decreased might be due to the characteristics of volatile of the test item and hydrolysis of the test item proceeded gradually with time during the exposure. This study was performed using semi-static replace regime at every 24 hours in order to hold the concentration of the test item as much as possible. Therefore, this study is thought to be appropriate as a test with the concentration around the solubility in the dilution water. This definitive study complied with the test conditions since the environmental conditions in the test were also within the suitable range. Since no adverse effect was found under the condition in the definitive study, it was concluded that the test item had no adverse acute effect on the test organisms at the concentration around the solubility in dilution water. In addition, it is supposed 13F-EtOH of the hydrolyzed product had the additive effect on the test organisms since no adverse effect was observed in the study although the measured concentrations of that in the test solution were 0.0179 to 0.284 mg/L.