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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Study period:
2017-01 to 2018-03
Data waiving:
other justification
Justification for data waiving:
other:
Justification for type of information:
As next step the final experimental design will be discussed with ECHA based on the available preliminary tests.
Qualifier:
according to
Guideline:
OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)

Description of key information

Key value for chemical safety assessment

Additional information

Based on the currently available data (no ready biodegradability, log Kow of 4.2) is has to be assumed that the substance may bioaccumulate in the food chain. In an acute oral toxicity study (Hüls 1985), slight signs of toxicity were observed such as diuresis, indicating bioavailability of the substance via the oral route to some extent. Therefore a bioaccumulation study in fish according to OECD 305 was proposed. Since the substance is a UCVB substance the test design will be arranged accordingly and in close agreement with the responsible authority. The test substance was found to be not hydrolytically stable. However, its components differ significantly in their liabilities to hydrolysis: For some of them the MS peak areas decreased in the course of the preliminary study while for others they increased. The total peak area decreased by 20-30 %, which, however, does not allow quantitative conclusions because of the variation of the sensitivity of the detection system towards differing molecular species.