Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-281-4 | CAS number: 98362-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-01-29 to 1986-02-04
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions: TA 102 or E.coli WP2 were not tested,
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
- Principles of method if other than guideline:
- Ames BN et al. (1975). Mutat. Res. 31, 347-364
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,3-Epoxypropyl neodecanoate, oligomeric reaction products with toluene-4-sulfonic acid
- EC Number:
- 500-281-4
- EC Name:
- 2,3-Epoxypropyl neodecanoate, oligomeric reaction products with toluene-4-sulfonic acid
- Cas Number:
- 98362-33-5
- Molecular formula:
- Exact identification is not feasible
- IUPAC Name:
- Copolymer of neodecanoic acid oxiranylmethyl ester and 4-methylbenzenesulfonic acid
- Reference substance name:
- Copolymer of neodecanoic acid oxiranylmethyl ester and 4 -methylbenzenesulfonic acid
- IUPAC Name:
- Copolymer of neodecanoic acid oxiranylmethyl ester and 4 -methylbenzenesulfonic acid
- Details on test material:
- not reported
Constituent 1
Constituent 2
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538
- Additional strain / cell type characteristics:
- not applicable
- Metabolic activation:
- with and without
- Metabolic activation system:
- Arochlor induced rat S9 fraction
- Test concentrations with justification for top dose:
- 10, 25, 50, 100, 200, 250, 1000, 5000 µg/plate
- Vehicle / solvent:
- DMSO
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- no
- Positive controls:
- other: except simultaneous test of several substances including one positive result
- Details on test system and experimental conditions:
- Type: Ames test
ADMINISTRATION:
- Number of replicates: 2
- Application: Solvent dimethyl sulfoxide (CAS No. 67-68-5)
- Positive and negative control groups and treatment:
Negative: Blank
Positive: None (except simultaneous test of several substances including one positive result)
- Incubation: 4 days - Evaluation criteria:
- CRITERIA FOR EVALUATING RESULTS: Mutagenic effects (i.e ratio of revertant rates treated/control >= 2)
Results and discussion
Test results
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Remarks:
- with metabolic activation, depending on strain, see results for details
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Additional information on results:
- no further information
- Remarks on result:
- other: other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
CYTOTOXIC CONCENTRATION: none
GENOTOXIC EFFECTS:
without metabolic activation: none with
metabolic activation: TA 100: >= 50 µg/plate
TA 1535: >= 25 µg/plate TA 98: none TA 1537: none TA 1538: none
Applicant's summary and conclusion
- Conclusions:
- The mutagenic effect in the in vitro bacterial mutagenicity test is induced by not reacted 2,3-epoxypropyl neodecanoate, which is mutagenic in vitro.
- Executive summary:
Under the conditions employed in the Salmonella reverse mutation assay,
2,3-Epoxypropyl neodecanoate, oligomeric reaction products with toluene-4-sulfonic acid
was mutagenic with metabolic activation in strain TA1535 at doses higher 25 ug/plate and in strain TA100 at doses higher than 50 ug/plate.
However, the mutagenic effect in the in vitro bacterial mutagenicity test is induced by not reacted 2,3-epoxypropyl neodecanoate, which is mutagenic in vitro.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.