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EC number: 692-614-6
CAS number: 5660-53-7
Individual grading of eye reactions (scores)
mean values calculated as the mean scores of readings at 24, 48 and 72
presence of ulcer
eye irritation study was performed with
2-isobutyl-2-methyl-1,3-dioxolane-4-methanol in New Zealand White
rabbits according to the OECD 405 Guideline and in compliance with the
rabbits were employed. The test substance (0.1 mL) was applied undiluted
into the left eye of each rabbit. The contralateral eye was used as
control. The eyes of the rabbits were then evaluated at various times
after application (1, 24, 48 and 72 hours for the first animal tested
and 1, 24 and 48 hours for the second and third animals tested) for
signs of ocular reactions in the iris, cornea and conjunctivae.
Irritation was scored according to the Draize method.
toxicity or abnormality in body weight gain was detected during the
first animal tested, conjunctivae redness, chemosis and iritis were
observed during evaluation of 1, 24 and 48 hours. Opacity was observed
at 1 hour of evaluation until 24 hours. On day 3, all ocular effects
were reverted. In the second and third animals tested, corneal opacity,
iritis, chemosis and conjunctival redness were observed during
evaluations of 1, 24 and 48 hours. At 48 hours, corneal ulceration,
considered irreversible lesion, was observed and the test was
conclusion, 2-isobutyl-2-methyl-1,3-dioxolane-4-methanol requires
classification as eye corrosive (Category 1; irreversible effects on the
eye) according to the Regulation (EC) 1272/2008 (CLP) and GHS UN
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