Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 692-614-6
CAS number: 5660-53-7
No mortality nor treatment related clinical
signs were observed during the observation period.
No effect on body weight gain was reported.
An acute skin irritation study was performed
with 2-isobutyl-2-methyl-1,3-dioxolane-4-methanol in New Zealand White
to the OECD 404 Guideline and in compliance with the GLP.
male rabbits were employed. The test substance (0.5 mL) was applied
undiluted to an area of 6 cm2 of the left flank previously shaved and
covered with a gauze patch. Adjacent non-treated areas of the right
flank were used as control. After 4 hours, residual test substance was
removed using deionized water. The animals were observed at 1, 24, 48
and 72 hours after patch removal to assess the signs of erythema and
edema according to the Draize method. Additionnal general examinations
were performed daily.
systemic toxicity or abnormality in body weight gain occured during the
observation period. No edema or erythema was observed at 1, 24, 48 and
72 hours in any animals. Test was concluded at 72 hours since no
reaction was observed.
conclusion, 2-isobutyl-2-methyl-1,3-dioxolane-4-methanol does not
require classification as a skin irritant according to
the Regulation (EC) 1272/2008 (CLP) and GHS UN criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Na ovom portalu koristimo kolačiće kako bismo vam osigurali najbolje iskustvo njegova pregledavanja.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again