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EC number: 692-614-6
CAS number: 5660-53-7
No mortality nor treatment related clinical
signs were observed during the observation period.
No effect on body weight gain was reported.
An acute skin irritation study was performed
with 2-isobutyl-2-methyl-1,3-dioxolane-4-methanol in New Zealand White
to the OECD 404 Guideline and in compliance with the GLP.
male rabbits were employed. The test substance (0.5 mL) was applied
undiluted to an area of 6 cm2 of the left flank previously shaved and
covered with a gauze patch. Adjacent non-treated areas of the right
flank were used as control. After 4 hours, residual test substance was
removed using deionized water. The animals were observed at 1, 24, 48
and 72 hours after patch removal to assess the signs of erythema and
edema according to the Draize method. Additionnal general examinations
were performed daily.
systemic toxicity or abnormality in body weight gain occured during the
observation period. No edema or erythema was observed at 1, 24, 48 and
72 hours in any animals. Test was concluded at 72 hours since no
reaction was observed.
conclusion, 2-isobutyl-2-methyl-1,3-dioxolane-4-methanol does not
require classification as a skin irritant according to
the Regulation (EC) 1272/2008 (CLP) and GHS UN criteria.
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