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EC number: 692-614-6
CAS number: 5660-53-7
tested for acute dermal toxicity in Sprague-Dawley rats in a
GLP-compliant limit dose assay according to OECD guideline 402. Groups
of rats (5/sex) were administered a single dermal dose of undiluted test
material at 2000 mg/kg bw on clipped skin (approximately 10 % of the
total body surface area) using a semi-occlusive patch held in place for
24 h. Residual test item was removed using a dry cotton pad at the end
of the 24 h exposure period. Examinations for mortality, clinical signs,
body weight gain and dermal reactions were performed during a 14-day
observation period. All surviving animals were necropsied at the end of
the observation period.
occurred during the observation period. When compared to historical
control animals, the mean body weight gain was unaffected by the test
item treatment in females. A lower mean body weight gain was noted in
males between day 1 and day 8 due to one animal which had lost weight
during this period. The mean body weight gain returned to normal
thereafter. This change in males was considered incidental. At necropsy,
macroscopic examination of main organs showed no abnormalities. The
acute dermal combined LD50 was greater than 2000 mg/kg bw.
changes were observed in some animals. On the application site, two
females presented scabs from day 11 or 12 and up to day 13 or 14, and a
very slight erythema was noted in one of these two females on days 3 and
4. No cutaneous reactions were observed in any males.
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