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EC number: 413-110-2
CAS number: 135861-56-2
A 28-day repeated-dose oral toxicity study of the test material followed
by a 14-day recovery test was conducted in male and female Crj: CD (SD)
rats (6/sex/ group), 5 weeks of age at the start of dosing. The highest
dose was set at 1000 mg/kg, and 3 lower doses at 200, 40 and 8 mg/kg.
Recovery groups were separately provided for vehicle control and 1000
There were no deaths on account of administration of the test material.
No abnormalities were noted in general conditions, body weights, food
consumption, haematological examinations, blood chemical examinations,
urinalysis, necropsy and histopathological examinations.
In organ weights, increased absolute and relative liver weights were
noted in males of the 1000 mg/kg group.
In the recovery test, no abnormalities were noted.
In conclusion, No Observed Effect Level of the test material for rats
was considered to be 200 mg/kg/day under the conditions tested.
The No Observed Adverse Effect Level was considered to be 1000 mg/kg/day.
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