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EC number: 413-110-2
CAS number: 135861-56-2
The 48-hour EC50 was determined to be > 0.10 mg/L. Correspondingly the No Observed Effect Concentration was ≥ 0.10 mg/L.
A study was performed to assess the acute toxicity of the test material
to Daphnia magna. The method followed that described in the OECD
Guidelines for Testing of Chemicals No. 202, "Daphnia sp,
Acute Immobilisation Test and Reproduction Test", referenced as Method
C.2 of Commission Directive 92/69/EEC.
Following a preliminary range-finding study, 40 daphnids (4 replicates
of 10 animals) were exposed to an aqueous dispersion of the test
material at a concentration of 0.1 0 mg/L for 48 hours under static test
conditions. lmmobilisation and any adverse reactions to exposure were
recorded after 24 and 48 hours.
The 48-Hour EC50 for the test material to Daphnia magna based
on nominal test concentrations was > 0.10 mg/L and correspondingly the
No Observed Effect Concentration was ≥ 0.10 mg/L.
The test concentration of 0.10 mg/L was the highest attainable test
concentration due to the limited solubility of the test material in
water and auxiliary solvent, and having due regard for the amount of
auxiliary solvent permitted in the test under the OECD Guidelines.
Analysis of the freshly prepared test solutions at 0 hours showed the
measured concentrations for the 0.10 mg/L test concentration to be 77 %
(replicates R1- R2pooled) and 80 % (replicates R3-
R4pooled) of nominal. These low results were considered to be
due to sampling and/or analytical variation given that analysis of
duplicate frozen samples gave measured concentrations of 84 % and 84 %
of nominal respectively. At 48 hours, measured concentrations in excess
of the required 80 % of nominal test concentrations were observed. It
was therefore considered justifiable to estimate the EC50 values
based on nominal test concentrations only.
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